Effector Repertoire of Salmonella T6SS 
📰 Citation
Nicastro, G.G., Sibinelli-Sousa, S., Hespanhol, J.T., et al. (2025)
Genome-directed study reveals the diversity of Salmonella T6SS effectors and identifies a novel family of lipid-targeting antibacterial toxins. bioRxiv.https://doi.org/10.1101/2024.09.27.615498
🔎 How to Use This Resource
This page provides curated information on Salmonella T6SS effector candidates identified in our genome-wide analysis. Each row in the table represents a specific effector group (e.g., STox_2), with links to the relevant data and structural models.
Each table on this page represents a broader thematic category of effector activity, grouping together toxins with similar molecular targets or biochemical mechanisms. You can navigate directly to each category below:
Each section contains a curated table of candidate effectors, their alignments, structural models, and predicted functions.
Columns include:
- Model: HMM model constructed in this study.
- BLAST: Link to run NCBI BLASTP using the reference sequence (first sequence in the alignment) as query against the NCBI nr database.
- Alignments: Multiple sequence alignments used to build the HMMs, available in HTML (with and without gaps) and in FASTA format for download. All alignments include NCBI protein accession numbers.
- HHpred: HHpred remote homology search results obtained using the full alignment as input.
- Group: Functional or structural classification (e.g., BECR fold).
- AlphaFold: Access to AlphaFold2-predicted 3D structures, with options to visualize them using Mol* or download in
.molx format.
Use the links in each row to explore and download sequences, alignments, and predicted structures.
Nuclease: DNase, RNase
| Model |
blast |
Alignment |
HHpred |
Group |
AlphaFold |
| STox_2 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| STox_6 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| STox_11 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| STox_37 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| STox_57 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| STox_58 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| STox_59 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| STox_60 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| Ntox19.st |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| Ntox18.st1 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| Ntox18.st2 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| Ntox49.st |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| Tox-Ribonuclease.st |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| Ntox47.st2 |
blast |
without gap, with gap, download |
HHpred |
BECR |
view download |
| STox_1 |
blast |
without gap, with gap, download |
HHpred |
BECR-like |
view download |
| STox_3 |
blast |
without gap, with gap, download |
HHpred |
BECR-like |
view download |
| STox_4 |
blast |
without gap, with gap, download |
HHpred |
BECR-like |
view download |
| STox_55 |
blast |
without gap, with gap, download |
HHpred |
BECR-like |
view download |
| Ntox7.st |
blast |
without gap, with gap, download |
HHpred |
BECR-like |
view download |
| Ntox47.st1 |
blast |
without gap, with gap, download |
HHpred |
BECR-like |
view download |
| STox_36 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| STox_53 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| STox_61 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| Tke2.st |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| Tox-AHH.st1 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| Tox-AHH.st2 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| Tox-AHH.st3 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| Tox-AHH.st4 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| Tox-WHH.st1 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| Tox-WHH.st2 |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| Tox-HNHGH-E.st |
blast |
without gap, with gap, download |
HHpred |
HNH |
view download |
| STox_54 |
blast |
without gap, with gap, download |
HHpred |
REase (PDDExK) |
view download |
| Tox-REase-7.st |
blast |
without gap, with gap, download |
HHpred |
REase (PDDExK) |
view download |
| Tox-REase-3/4.st |
blast |
without gap, with gap, download |
HHpred |
REase (PDDExK) |
view download |
| TseV |
blast |
without gap, with gap, download |
HHpred |
REase (PDDExK) |
view download |
| CdiA_C.st |
blast |
without gap, with gap, download |
HHpred |
REase (PDDExK) |
view download |
| ParBL.st1 |
blast |
without gap, with gap, download |
HHpred |
ParB/Sulfiredoxin |
view download |
| ParBL.st3 |
blast |
without gap, with gap, download |
HHpred |
ParB/Sulfiredoxin |
view download |
| ParBL.st2 |
blast |
without gap, with gap, download |
HHpred |
ParB/Sulfiredoxin |
view download |
| STox_7 |
blast |
without gap, with gap, download |
HHpred |
GIY-YIG |
view download |
| Tox-URI1.st |
blast |
without gap, with gap, download |
HHpred |
GIY-YIG |
view download |
| Tox-URI2.st |
blast |
without gap, with gap, download |
HHpred |
GIY-YIG |
view download |
| STox_14 |
blast |
without gap, with gap, download |
HHpred |
Ribonuclease A |
view download |
| Ntox34.st |
blast |
without gap, with gap, download |
HHpred |
Not determined (All-α) |
view download |
| Ntox44.st1 |
blast |
without gap, with gap, download |
HHpred |
Not determined (All-α) |
view download |
| Ntox44.st2 |
blast |
without gap, with gap, download |
HHpred |
Not determined (All-α) |
view download |
Deaminase
Peptidase
| Model |
blast |
Alignment |
HHpred |
Group |
AlphaFold |
| STox_19 |
blast |
without_gap, with gap, download |
HHpred |
Metallopeptidase |
view download |
| STox_41 |
blast |
without gap, with gap, download |
HHpred |
Metallopeptidase |
view download |
| STox_51 |
blast |
without gap, with gap, download |
HHpred |
Metallopeptidase |
view download |
| Tox-HopH1.st |
blast |
without gap, with gap, download |
HHpred |
Metallopeptidase |
view download |
| Tox-Peptidase M4.st |
blast |
without gap, with gap, download |
HHpred |
Metallopeptidase |
view download |
| Tox-Peptidase M23.st |
blast |
without gap, with gap, download |
HHpred |
Metallopeptidase |
view download |
| Tox-Caspase.st |
blast |
without gap, with gap, download |
HHpred |
Caspase-like |
view download |
| Tlde1.st2 |
blast |
without gap, with gap, download |
HHpred |
LD-Peptidase |
view download |
| Tlde1.st1 |
blast |
without gap, with gap, download |
HHpred |
LD-Peptidase |
view download |
| STox_44 |
blast |
without gap, with gap, download |
HHpred |
Papain-like peptidase |
view download |
| EvpQ.st |
blast |
without gap, with gap, download |
HHpred |
Papain-like peptidase |
view download |
| Tae2.st |
blast |
without gap, with gap, download |
HHpred |
Papain-like peptidase |
view download |
| Tae4.st |
blast |
without gap, with gap, download |
HHpred |
Papain-like peptidase |
view download |
ADP-ribosyltransferase
| Model |
blast |
Alignment |
HHpred |
Group |
AlphaFold |
| STox_12 |
blast |
without gap, with gap, download |
HHpred |
ADP-ribosyltransferase |
view download |
| STox_23 |
blast |
without gap, with gap, download |
HHpred |
ADP-ribosyltransferase |
view download |
| STox_62 |
blast |
without gap, with gap, download |
HHpred |
ADP-ribosyltransferase |
view download |
| TreTu.st |
blast |
without gap, with gap, download |
HHpred |
ADP-ribosyltransferase |
view download |
| RhsP2.st |
blast |
without gap, with gap, download |
HHpred |
ADP-ribosyltransferase |
view download |
| Tox-ART-HYD.st |
blast |
without gap, with gap, download |
HHpred |
ADP-ribosyltransferase |
view download |
| Tox-ART-HYD3.st |
blast |
without gap, with gap, download |
HHpred |
ADP-ribosyltransferase |
view download |
Glycosidase
| Model |
blast |
Alignment |
HHpred |
Group |
AlphaFold |
| STox_42 |
blast |
without gap, with gap, download |
HHpred |
Lysozyme-like |
view download |
| STox_46 |
blast |
without gap, with gap, download |
HHpred |
Lysozyme-like |
view download |
| STox_56 |
blast |
without gap, with gap, download |
HHpred |
Lysozyme-like |
view download |
| Tge2.st |
blast |
without gap, with gap, download |
HHpred |
Lysozyme-like |
view download |
| Pesticin.st |
blast |
without gap, with gap, download |
HHpred |
Lysozyme-like |
view download |
| STox_50 |
blast |
without gap, with gap, download |
HHpred |
Muramidase |
view download |
Phospholipase and Acyltransferase
Adenylyl cyclase
Phosphodiester glycosidase (NAGPA)
Not determined
| Model |
blast |
Alignment |
HHpred |
Group |
AlphaFold |
| STox_24 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_25 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_30 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_29 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_31 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_32 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_33 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_39 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_45 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |
| STox_49 |
blast |
without gap, with gap, download |
HHpred |
Not determined |
view download |