Nicastro, G.G., Sibinelli-Sousa, S., Hespanhol, J.T., et al. (2025) Genome-directed study reveals the diversity of Salmonella T6SS effectors and identifies a novel family of lipid-targeting antibacterial toxins. bioRxiv.https://doi.org/10.1101/2024.09.27.615498
This page provides curated information on Salmonella T6SS effector candidates identified in our genome-wide analysis. Each row in the table represents a specific effector group (e.g., STox_2), with links to the relevant data and structural models.
Each table on this page represents a broader thematic category of effector activity, grouping together toxins with similar molecular targets or biochemical mechanisms. You can navigate directly to each category below:
Each section contains a curated table of candidate effectors, their alignments, structural models, and predicted functions. Columns include:
Use the links in each row to explore and download sequences, alignments, and predicted structures.
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| STox_20 | without gap with gap | HHpred | Deaminase* | view download |
| ToxJAB2.st1 | without gap with gap | HHpred | Deaminase* | view download |
| ToxJAB2.st2 | without gap with gap | HHpred | Deaminase* | view download |
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| STox_19 | without_gap with gap | HHpred | Metallopeptidase | view download |
| STox_41 | without gap with gap | HHpred | Metallopeptidase | view download |
| STox_51 | without gap with gap | HHpred | Metallopeptidase | view download |
| Tox-HopH1.st | without gap with gap | HHpred | Metallopeptidase | view download |
| Tox-Peptidase M4.st | without gap with gap | HHpred | Metallopeptidase | view download |
| Tox-Peptidase M23.st | without gap with gap | HHpred | Metallopeptidase | view download |
| Tox-Caspase.st | without gap with gap | HHpred | Caspase-like | view download |
| Tlde1.st2 | without gap with gap | HHpred | LD-Peptidase | view download |
| Tlde1.st1 | without gap with gap | HHpred | LD-Peptidase | view download |
| STox_44 | without gap with gap | HHpred | Papain-like peptidase | view download |
| EvpQ.st | without gap with gap | HHpred | Papain-like peptidase | view download |
| Tae2.st | without gap with gap | HHpred | Papain-like peptidase | view download |
| Tae4.st | without gap with gap | HHpred | Papain-like peptidase | view download |
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| STox_12 | without gap with gap | HHpred | ADP-ribosyltransferase | view download |
| STox_23 | without gap with gap | HHpred | ADP-ribosyltransferase | view download |
| STox_62 | without gap with gap | HHpred | ADP-ribosyltransferase | view download |
| TreTu.st | without gap with gap | HHpred | ADP-ribosyltransferase | view download |
| RhsP2.st | without gap with gap | HHpred | ADP-ribosyltransferase | view download |
| Tox-ART-HYD.st | without gap with gap | HHpred | ADP-ribosyltransferase | view download |
| Tox-ART-HYD3.st | without gap with gap | HHpred | ADP-ribosyltransferase | view download |
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| STox_42 | without gap with gap | HHpred | Lysozyme-like | view download |
| STox_46 | without gap with gap | HHpred | Lysozyme-like | view download |
| STox_56 | without gap with gap | HHpred | Lysozyme-like | view download |
| Tge2PP.st | without gap with gap | HHpred | Lysozyme-like | view download |
| Pesticin.st | without gap with gap | HHpred | Lysozyme-like | view download |
| STox_50 | without gap with gap | HHpred | Muramidase | view download |
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| STox_15 | without gap with gap | HHpred | Papain-like peptidase | view download |
| TseH.st | without gap with gap | HHpred | Papain-like peptidase | view download |
| Tle1.st | without gap with gap | HHpred | α/β hydrolase | view download |
| Tle3.st | without gap with gap | HHpred | α/β hydrolase | view download |
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| STox_17 | without gap with gap | HHpred | Colicin-like | view download |
| STox_18 | without gap with gap | HHpred | Not determined | view download |
| VasX.st | without gap with gap | HHpred | Colicin-like | view download |
| Ssp6.st | without gap with gap | HHpred | Not determined | view download |
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| ExoY.st | without gap with gap | HHpred | Polymerase β superfamily nucleotidyltransferase | view download |
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| STox_35 | without gap with gap | HHpred | Phosphodiester glycosidase | view download |
| Model | Alignment | HHpred | Group | AlphaFold |
|---|---|---|---|---|
| STox_24 | without gap with gap | HHpred | Not determined | view download |
| STox_25 | without gap with gap | HHpred | Not determined | view download |
| STox_30 | without gap with gap | HHpred | Not determined | view download |
| STox_29 | without gap with gap | HHpred | Not determined | view download |
| STox_31 | without gap with gap | HHpred | Not determined | view download |
| STox_32 | without gap with gap | HHpred | Not determined | view download |
| STox_33 | without gap with gap | HHpred | Not determined | view download |
| STox_39 | without gap with gap | HHpred | Not determined | view download |
| STox_45 | without gap with gap | HHpred | Not determined | view download |
| STox_49 | without gap with gap | HHpred | Not determined | view download |